Maternal and Paternal Age and Risk of Autism Spectrum Disorders

Maternal and paternal age and risk of autism spectrum disorders.

OBJECTIVE To explore the association between maternal and paternal age and risk of autism spectrum disorders (ASDs) in offspring. DESIGN Historical birth cohort study. SETTING Kaiser Permanente (KP) in Northern California. PARTICIPANTS All singleton children born at KP from January 1, 1995, to December 31, 1999, were included in the study. We identified 593 children who had ASD diagnoses ...

Advancing Paternal Age and Risk of Autism

Maternal lifestyle and environmental risk factors for autism spectrum disorders.

BACKGROUND Over the past 10 years, research into environmental risk factors for autism has grown dramatically, bringing evidence that an array of non-genetic factors acting during the prenatal period may influence neurodevelopment. METHODS This paper reviews the evidence on modifiable preconception and/or prenatal factors that have been associated, in some studies, with autism spectrum disord...

Risk of autism and increasing maternal and paternal age in a large north American population.

Previous studies are inconsistent regarding whether there are independent effects of maternal and paternal age on the risk of autism. Different biologic mechanisms are suggested by maternal and paternal age effects. The study population included all California singletons born in 1989-2002 (n = 7,550,026). Children with autism (n = 23,311) were identified through the California Department of Dev...

Parental age and autism spectrum disorders.

PURPOSE We sought to study the possible association between parental age and autism spectrum disorder (ASD) by using both a cohort design and a sibling design. METHODS Our cohort included all singleton births in Denmark from January 1, 1980, through December 31, 2003, a total of 1,311,736 children. Cases of ASDs were obtained from the Danish National Psychiatric Register using International C...